Some research facts about SARMs, Nootropics and other substances you can buy from Enhancetech:

 

  • PRL-8-53 improved novel word recall after a week in bottom 60% learners by 200%.
  • There is only one white paper about PRL-8-53, yet it was considered the most reliable memory enhancing agent by nootropics community quiz.
  • Contrary to common myths, there is no proof that cardarine reduces weight or waist circumference; actually, the opposite may be likelier.
  • Cardarine increased running endurance in Kunming mice. World Anti-Doping Agency banned it.
  • Cardarine prevented endoplasmatic reticulum stress and insulin resistance in mice fed high-fat diet.
  • Cardarine, 10 mg, reduced plasma triglycerides, LDL-cholesterol, insulin and urinary 8-isoprostanes in man.
  • At low, 2.5 mg dose, Cardarine had a highly specific effect – it increased “good” HDL cholesterol.
  • There were 275 studies pertinent for GW501516 (cardarine) in PubMed.
  • Cardarine had a unfavourable interaction with posttraumatic cartilage.
  • Ostarine was unlikely to cross blood-brain barrier according to in silico predictions.
  • Ostarine (3 mg) and ibutamoren (25 mg) increased lean body mass in older adults without overt short-term toxicity.
  • Ostarine (3 mg) had low incidence of adverse effects in the elderly.
  • According to many online discussions, elevated doses of ostarine have suppressed endogenous testosterone levels.
  • Majority of the research related to relatively unresearched Ligandrol is related to detection of metabolites for doping control.
  • Ligandrol is quite potent but unselective SARM – it increases lean body mass but suppresses endogenous sex hormone levels even at 1 mg dose.
  • Ibutamoren has been considered quite safe in many studies but unsafe for elderly – it increased risk of congestive heart failure.
  • Ibutamoren increased blood glucose, insulin and cortisol – these may be unfavourable changes. Blood sugar elevation is greatest concern.
  • Both SARMs and ibutamoren probably increase bone mineral density.
  • Ibutamoren lowered total blood testosterone but not free testosterone.
  • Unlike exogenous growth hormone, ibutamoren increases secretion of growth hormone by its natural, pulsatile pattern.
  • Lab rat nootropic unifiram is not tested in humans, yet.
  • Unifiram’s pro-cognitive mechanism of action enhances AMPA signalling and acetylcholine release but exact mechanism is unclear.
  • Contrary to the common myths, Cardarine, Ibutamoren and YK-11 are not SARMs (selective androgen receptor modulators).
  • YK11 is a minimally researched SARM-like steroid that is selective for muscle growth.
  • Boron (3 mg) has memory-enhancing, anti-inflammatory and sex hormone enhancing properties. Yet, it is merely a underrated micronutrient.
  • The toxicity of boron has been overestimated and its beneficial effects underestimated.
  • Boron supplementation increases free testosterone, reduces estradiol and decreases sex hormone binding globulin.