Some research facts about SARMs, Nootropics and other substances you can buy from Enhancetech:
-
PRL-8-53 improved novel word recall after a week in bottom 60% learners by 200%.
-
There is only one white paper about PRL-8-53, yet it was considered the most reliable memory enhancing agent by nootropics community quiz.
-
Contrary to common myths, there is no proof that cardarine reduces weight or waist circumference; actually, the opposite may be likelier.
-
Cardarine increased running endurance in Kunming mice. World Anti-Doping Agency banned it.
-
Cardarine prevented endoplasmatic reticulum stress and insulin resistance in mice fed high-fat diet.
-
Cardarine, 10 mg, reduced plasma triglycerides, LDL-cholesterol, insulin and urinary 8-isoprostanes in man.
-
At low, 2.5 mg dose, Cardarine had a highly specific effect – it increased “good” HDL cholesterol.
-
There were 275 studies pertinent for GW501516 (cardarine) in PubMed.
-
Cardarine had a unfavourable interaction with posttraumatic cartilage.
-
Ostarine was unlikely to cross blood-brain barrier according to in silico predictions.
-
Ostarine (3 mg) and ibutamoren (25 mg) increased lean body mass in older adults without overt short-term toxicity.
-
Ostarine (3 mg) had low incidence of adverse effects in the elderly.
-
According to many online discussions, elevated doses of ostarine have suppressed endogenous testosterone levels.
-
Majority of the research related to relatively unresearched Ligandrol is related to detection of metabolites for doping control.
-
Ligandrol is quite potent but unselective SARM – it increases lean body mass but suppresses endogenous sex hormone levels even at 1 mg dose.
-
Ibutamoren has been considered quite safe in many studies but unsafe for elderly – it increased risk of congestive heart failure.
-
Ibutamoren increased blood glucose, insulin and cortisol – these may be unfavourable changes. Blood sugar elevation is greatest concern.
-
Both SARMs and ibutamoren probably increase bone mineral density.
-
Ibutamoren lowered total blood testosterone but not free testosterone.
-
Unlike exogenous growth hormone, ibutamoren increases secretion of growth hormone by its natural, pulsatile pattern.
-
Lab rat nootropic unifiram is not tested in humans, yet.
-
Unifiram’s pro-cognitive mechanism of action enhances AMPA signalling and acetylcholine release but exact mechanism is unclear.
-
Contrary to the common myths, Cardarine, Ibutamoren and YK-11 are not SARMs (selective androgen receptor modulators).
-
YK11 is a minimally researched SARM-like steroid that is selective for muscle growth.
-
Boron (3 mg) has memory-enhancing, anti-inflammatory and sex hormone enhancing properties. Yet, it is merely a underrated micronutrient.
-
The toxicity of boron has been overestimated and its beneficial effects underestimated.
-
Boron supplementation increases free testosterone, reduces estradiol and decreases sex hormone binding globulin.