Ibutamoren is analogue of hunger hormone ghreline. Ibutamoren amplifies the release of growth hormone according to its natural pattern of its release (this may be better than growth hormone injection, which does not follow that natural pattern). In scientific clinical studies, 25 mg dose has yielded positive results with good tolerability and no or minimal adverse events except increased likelihood of congestive heart insufficiency in the elderly study. It is considered a doping substance. Effects:
- Increased muscle mass
- Improved sleep quality
- Increased appetite
- Facilitation of regenerative processes
- Increased bone mineral density
- Lowering LDL-cholesterol
- Lowers insulin sensitivity and increases cortisol level
Read more about Ibutamoren.
RAD140 is a novel selective androgen receptor modulator (SARM), which selectively supports muscle growth over prostate growth when compared with testosterone. Read more about RAD140.
Cardarine is agonist of PPAR? receptor that intensifies lipid metabolism. It makes the body to use lipids more effectively – the metaphor of “lipid burning” seems very much applicable. It seems to have an effect that must be very attractive in association with typical adverse effects of the western diet. Cardarine alone is most probably insufficient to cause weight loss without altering the energy intake / energy use balance. The effects of cardarine appear as quite exact opposite to the stereotypical “bad western diet”, including alteration of “bad” LDL and “good” HDL cholesterol levels. It has different effects in different doses according to clinical studies:
Table – Dose-dependent effects of cardarine at six weeks:
|Free fatty acids||–||–||–|
Cardarine has immunomodulatory properties (it lowers IL-6 levels). Cardarine and PPAR-delta in general is under scrutiny because it can support or suppress tumor cell activity. Cardarine is considered as a doping substance.
- Increased endurance
- Improvement of blood profile that has been associated with high-carb high-fat diet
- Immunomodulation (reduction of IL-6)
- Weight gain in higher doses
Read more about Cardarne.