Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARM). In a short (21-day) placebo-controlled human study, participants gained lean body mass, alongside expected hormonal suppression.
RAD140 (Testolone) is another SARM. Most of what we know comes from preclinical work describing potent, tissue-selective androgen-receptor activity.
Ibutamoren (MK-677) isn’t a SARM. It’s an oral growth-hormone secretagogue (a ghrelin-receptor agonist) that raises GH and IGF-1. Human trials show increases in IGF-1 and, in select groups, fat-free mass during treatment.
Where a “stack” might seem complementary
Think of two anabolic highways working in parallel:
- Androgen-receptor signaling (LGD-4033, RAD140) is tied to muscle protein synthesis and strength adaptations.
- GH/IGF-1 signaling (MK-677) can influence recovery, sleep quality for some users, and nitrogen retention.
In theory, combining them could target distinct pathways that together support hypertrophy and training tolerance. In practice, controlled human data on the combination are lacking, so “synergy” is a mechanistic hypothesis, not a clinical fact.
How long until you might see anything?
Meaningful body-composition changes rarely appear overnight. Trials with MK-677 and LGD-4033 measured hormonal and lean-mass shifts over weeks to months, and effects typically persisted only while on treatment. If you’re going to evaluate a program built around these compounds, a minimum of ~3 months is a realistic appraisal window. Conveniently, Enhancetech’s “Gain Force” kit is packaged as a three-month supply of Ligandrol, RAD140 and Ibutamoren.
Expect to assess results no sooner than ~12 weeks of consistent training, nutrition and sleep. Anything shorter is hard to judge.
Important caveats & compliance
The FDA has cautioned consumers about SARMs due to potential risks (including liver injury and cardiovascular events) and the fact that these are unapproved for human use.
LGD-4033 and RAD140 are prohibited at all times by WADA. Athletes subject to anti-doping rules should avoid them altogether.
MK-677 can impair glucose tolerance in some settings, and SARMs have been linked (in case reports/series) with liver injury. Medical supervision is prudent.
Where to find the SARMS stack
Our e-shop offers the “Gain Force” kit (LGD-4033 + RAD140 + MK-677) specifically as a 3-month bundle aimed at strength, mass and recovery support per vendor description.
References
Basaria S, et al. The Safety, Pharmacokinetics, and Effects of LGD-4033… (21-day human trial).
Miller CP, et al.; ACS Med Chem/PMC: discovery & characterization of RAD140 (preclinical). American Chemical Society Publications.
Nass R, et al. Effects of an Oral Ghrelin Mimetic (MK-677) on Body Composition and Clinical Outcomes in Older Adults.
Svensson J, et al. Two-month MK-677 in healthy obese men: sustained GH/IGF-1 rise; OGTT impairment. PubMedSmith RG, 2023 review of growth-hormone secretagogues (duration-dependent effects). Oxford Academic.
