Unveiling the Potential: How SARMS Help Control Bad Cholesterol

Unveiling the Potential: How SARMS Help Control Bad Cholesterol

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In the quest for physical fitness and wellness, the landscape of supplements and performance enhancers is ever-evolving. One category that has garnered attention in recent years is Selective Androgen Receptor Modulators, or SARMS. While primarily known for their muscle-building properties, SARMS also hold promise in managing cholesterol levels, specifically bad cholesterol, or LDL (Low-Density Lipoprotein). Let’s delve into how SARMS might be a potential ally in the battle against high LDL cholesterol.

Understanding Cholesterol

Before we explore the relationship between SARMS and cholesterol, it’s crucial to grasp the role of cholesterol in the body. Cholesterol is a waxy, fat-like substance found in every cell of the body and is essential for building cell membranes, producing hormones, and aiding in the digestion of fat. However, when cholesterol levels become imbalanced, it can lead to atherosclerosis, a condition characterized by the accumulation of plaque in the arteries, increasing the risk of heart disease and stroke.

Cholesterol exists in different forms within the body. High-Density Lipoprotein (HDL) is often referred to as “good” cholesterol as it helps remove LDL from the arteries, transporting it to the liver for excretion. On the other hand, LDL, or “bad” cholesterol, can build up in the arteries, leading to blockages and potentially dangerous health conditions.

SARMS: More Than Muscle Builders?

Selective Androgen Receptor Modulators were initially developed to treat conditions like muscle wasting and osteoporosis. They work by selectively binding to androgen receptors in the body, influencing gene expression that leads to muscle growth and bone density improvement. However, recent research suggests that SARMS might have additional benefits beyond their primary muscle-building function.

The Link Between SARMS and Cholesterol

While studies on SARMS are still in their infancy compared to other pharmaceuticals, there is emerging evidence to suggest that SARMS could impact cholesterol levels. One study published in the Journal of Pharmacology and Experimental Therapeutics found that a specific SARM known as S-23 and RAD-140 demonstrated a significant reduction in LDL cholesterol levels in rats. Similarly, another study published in the Journal of Steroid Biochemistry and Molecular Biology reported that another SARM, GTx-024 (also known as enobosarm or ostarine), decreased LDL cholesterol levels in monkeys.

These findings are promising, indicating that SARMS might not only enhance physical performance but also contribute to cardiovascular health by lowering LDL cholesterol levels. However, it’s essential to note that research on SARMS and cholesterol in humans is limited, and more comprehensive studies are needed to fully understand their effects and potential benefits.

In Conclusion

While SARMS hold promise as a potential tool in managing cholesterol levels, particularly LDL cholesterol, more research is needed to validate their efficacy and safety in humans. As of now, lifestyle modifications such as regular exercise, a balanced diet, and medication prescribed by healthcare professionals remain the cornerstone of cholesterol management.

As the scientific community continues to explore the multifaceted effects of SARMS, it’s essential to approach their use with caution and prioritize evidence-based practices in pursuit of optimal health and wellness.


SARMs Comparison table

SARMs Comparison table

SARMs, SARMs online shop

Cardarine, Ostarine and Ibutamoren are very different performance-enhancing research chemicals SARMs. All three have been moderately well researched.

Cardarine increases endurance and lipid metabolism. I´ts microdose elevates good cholesterol.

Ostarine mimics the anabolic effects of testosterone more selectively than anabolic steroids. It´s relatively non-toxic; alas, users of high doses have been hospitalized due to adverse effects similar to anabolic steroids (liver toxicity).

Ibutamoren is a synthetic analogue of hunger hormone. That alters the intensity rather than pattern of growth hormone secretion.

Larger doses have probably higher risk of adverse effects. Recently, it was even suggested that cardarine is dangerous when combined with a SARM (ostarine). While it may tempting to think that cardarine would be a good means to reduce the side effects of SARMs or ibutamoren, it may be a bad idea. Recently, it was suggested that combination of cardarine and ostarine is toxic. At least after prolonged use of the combination. The following table shows both desirable and undesirable effects of these three major performance-enhancing chemicals.


















Michael’s feedback

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Hi Enhancetech

Here’s a picture of me taken 2 months between this summer. In this period I used cardarine and ostarine. I combination with 2/4 protein, 1/4 carbs and 1/4 fats I felt the shredding process even after a few days. Luckily, as you can see, I had noticable gains in muscle size too.

Great products which I will use over and over again! Very pleased.

Kind regards,


Igor Buracof feedback

Igor Buracof feedback

Customers Feedback, SARMs, SARMs online shop

Hello everyone

I would like to share my personal experience with SARMS to be more precisely the experience was only with SARMS made from enhancetech.
I started to take SARMS around 20/nov/2020. In the beginning I was bulking and it gave me a lot of strength, stamina and power during the workout session, I was into and RAD140, LGD-4033 and YK11 .
Then I moved to cut using MK-677 and RAD140. Was around 80 days with this cycle and it worked greatly. I would like to share bellow my before and after picture.

Igor Buracof

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Igor on the beach today

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Weight loss: causes and options


The current pharmaceutical options such as lorcaserin have clearly not been an adequate solution to problem of obesity. Extreme measures such as surgery, mitochondrial decouplers, tapeworm ingestion and illegal stimulants are not discussed.

While weight gain may be caused by medical conditions that alter water balance, commonly the weight gain is understood as accumulation of fatty tissue. Fatty tissue is caused by excess energy intake and deficit of energy expenditure (production of work, production of heat and bypass). In a biological system, such as a human, the energy intake is regulated first by availability, then by appetite and finally, by bioavailability of energy sourches such as fat, sugar, alcohol and protein. Assuming that food as an energy source is available, the energy intake is mainly regulated by appetite unless there is an overt mechanism that causes loss of energy sources, such as digestion disorders.

At the fundamental, biochemical level, there are certain biomolecules that increase or decrease appetite. Originating from the gut, Ghrelin is the primary hormone that creates sense of hunger [1] while, also originating from the gut, anorectic hormone peptide YY3-36 (PYY), cholecystokinine (CCK) and glucagon-like peptide-1 (GLP-1) reduce the appetite in response to energy intake and reduce reward to food intake in the responsible brain parts. Bile acids have an important role: these stimulate PYY and GLP-1 as well as modulate gut microbiota, which participates in appetite regulation in the one hand and energy accumulation efficiency in the other hand [2].

Fatty tissue, by default, “should” inhibit food intake by signalling via leptin and insulin that no more energy is necessary. However, due to cultural pecularities of food overconsumption in certain geographical regions especially, metabolic syndrome may be acquired. Metabolic syndrome is characterized by resistance to insulin (and probably leptin), and it is a risk factor for cardiovascular diseases and type 2 diabetes [3]. Insulin and/or leptin resistance destroys appetite control. Hence, obese people may feel hungry, probably against both their better judgement and superfluous energy reserves.

Food has hedonic reward, taste influences food intake. Food industries and art of culinary have been competing to produce as tasty foods as possible for generations. Children like sugar, for example. Considering these preferences, it is probably no wonder that corn flakes, former healthy food, has become sweeter and sweeter during course of the history [4]. In the same time, in some areas with well-entrenched healthier cuisine, such as Japan, do not experience obesity epidemic to an extent comparable to, for example, USA or Saudi Arabia. Technically, it is not even an addiction [5], and sugar preference is used in animal studies of a marker of normal enjoyment [6] despite having some traits that are sought to identify addictive substances such as dopamine and endorphin release in pleasure center of the brain [7]. While classifications may be of great academic interest, the desire to consume sweets may be comparable to desire to addictive substances and this clearly identifies it as an practical problem. It must be solved lest the situation be determined by rather hard-wired appetite and competition of capitalist food industry[8]. However, tastes can be acquired – for example when a child becomes accustomed to healthy food, that child develops a a preference for healthy food (reviewed in [1]). Taken that into account, the aquired taste of obesity-causing food is the major interventable culprit of obesity behind “junk food” eating cultures that can be identified from the world obesity maps readily available with the help of online search engines. Indeed, genetics plays a part, about 20% according to a huge population based genome-wide population study [9]. It is known that the americans of japanese origin have above-average rates of diabetes in USA [10]. Japan has experienced infiltration of western-like foods such as instant noodles to everyday diet of the japanese, and now the prevalence of type II diabetes or glucose resistance in Japan is 13.5% [11]. However, in Japan people tend to walk instead of driving, eat different foods and do not accept obesity as ‘normal’, and rate of their obesity is much lower than everywhere else in the world. Hence, the nutritional solution is exercise combined with diet of Japan 1975 (it was the maximally healthy one according to analysis) [12]. While the debate about the superiority of low-fat or low-carb diet is continuing in mainstream media, in the scientific literature the debater is more or less over. Low-carb diet and Mediterranean diet are clearly superior to low-fat approach [13], far superior.

Pharmaceutical solutions are at best secondary, unclear at worst. Surgery is the last resort. There are certain other add-on interventions provided by cosmetic industry but these, too, are supplementary. The primary interventions are exercise and diet. The supremacy of (A) traditional Japanese diet, (B) low-carb diet (see also ketogenic diet) and (C) traditional Mediterranean diet are established and most likely, must be part of the solution.

[1] https://pubmed.ncbi.nlm.nih.gov/28229538/
[2] https://pubmed.ncbi.nlm.nih.gov/28356427/
[3] https://pubmed.ncbi.nlm.nih.gov/24582089/
[4] https://www.diabetes.co.uk/blog/2015/03/sugar-in-cereal-who-are-the-worst-offenders/
[5] https://pubmed.ncbi.nlm.nih.gov/27372453/
[6] https://rndb.clps.brown.edu/task/sucrose-preference-test/
[7] https://pubmed.ncbi.nlm.nih.gov/20648910/
[8] https://pubmed.ncbi.nlm.nih.gov/23719144/
[9] https://pubmed.ncbi.nlm.nih.gov/25673413/

Alternatives to testosterone replacement


Recently, a study has been published that considers testosterone restoration as an alternative to testosterone replacement. In aging male, the testosterone levels become lower but generally support sufficient testosterone levels. However, the low-normal levels of testosterone have been associated (causation not implied) with higher levels of mortality, about 35% all-cause mortality [2].

Human Corion Gonadotrophin (HCG) is a powerful hormone that can, in low doses, restore testosterone production but it has caused reduction of testicular volume and fertility parameters [1]. It has been to restore testosterone production of steroid abusers. In otherwise healthy men with low testosterone (<420 ng/dL-1) did not show expected increas in strength but caused significant reduction of testicular volume, gonadotrophin levels and, in a few cases, nipple tenderness. However, improved lean body mass was observed. Hence, long-term use of HGC therapy comes with significant side effects.

Antiestrogens such as clomiphene citrate (CC) counteracts effects of estrogens that give negative feedback to production of upstream sex hormones that promote production of testosterone [1]. Indeed, CC restored levels of follicles stimulating hormone FSH, luteinizing hormone LH and gonadotropin releasing hormone GnRH. While CC has consistently restored production of testosterone, effects on fertility and semen parameters have been variable, especially in older men were refractory to hormone manipulation while younger men had side effects of decreased libdo, lack of energy, decreased sports performance and worse mood.

Third group of anti-estrogenic treatment that aims to restore testosterone levels are aromate ihibitors AI such as anastrozole and letrozole. Since these drugs do not eliminate production of estrogens in men completely, these drugs are unlikely to cause osteoporosis in men. AI are more effective in raising testosterone levels than transdermal forms of testosterone such as testosterone gel [1]. The side effects of AI are minimal, mainly limited to unalarmingly modest increase of prostate specific antigen PSA (biomolecule used assess prostate pathology).

Fourth group is SARMs [3] or selective androgen receptor modulators such as ostarine, a “field leader”. Ostarine support smuscle growth and does not affect or even suppresse prostate growth, and does not significantly suppressing endogenous androgen production in clinically used doses. However, the selectivity of SARMs is not absolute, potency and selectivity appears to be a trade-off. A potent SARM such as ligandrol suppresses endogenous testosterone and also high density cholesterol – these side effects resembe side effects anabolic steroids [4]. SARMS can be expected to have cognition preserving results, some very low (cell culture) level studies with SARMS such as RAD-140 and NEP20 appear to support the theory [5,6].

Finally, some herbal medicines can improve aspects of androgen deficiency. Tribulus terrestris has been reviewed thorouhghly but with mainly positive effects in focus [7]. T. terrestris increases sex drive, appears to have properties that protect heart and blood vessels as well as nervous system from insults, has anti-inflammatory properties. Hovever, the abilities of tribulus terrestris to inreace endurance in rodents could not be replicated in controlled studies with human subjects [8,9]. Eurycoma longifolia is a herbal supplement with respectable traditional use with drawback of relatively high price, widespread distribution of fake extracts, and low bioavailability (10%) of main constituent eurycomanone (tested in rodents). Eurycoma longifolia has been reviewed comprehensively, and it has been tested in humans, mostly in association with aphrodisiac properties[10]. While E. longifolia has not been to subject of thorough exercise research, it seems to modestly improve testosterone levels, fertility parameters and libido on men with late onset hypogonadism, with additional benefits of being anti-diabetic, promoting bone strength and reducing anxiety.


Effects of Ibutamoren on brain

Nootropics, SARMs

It seems that short-term use of ibutamoren after short-term stress reduces anxiety while long-term use during chronic stress increases anxiety. In this post we introduce effects of Ibutamoren on brain

A new paper [1] describes a mechanism wherein a ghrelin mimetic (ibutamoren mesylate) can enhance fear learning in rats in the context of chronic stress. The said mechanism showed that a ghrelin agonist did not activate HPA stress axis, whose downstream effector hormone is cortisol. Ghrelin is a stress hormone by itself. Growth hormone receptors were up-regulated during repeated stressful events. Ghrelin agonist increased growth hormone levels and the fear learning of the rats grew in response to growth hormone. The mechanism was confirmed by using ghrelin antagonist that blocked the enhanced fear learning. In case of the short time frame, the opposite seems to be true, as short time stress followed by ghrelin agonist reduces stress symptoms in mice [2].

Fourth study also demonstrated that ghrelin weakens fear learning in generally unstressed rodents while chronically stressed rats had elevated levels of hunger hormone and fear learning ended up with fewer ghrelin receptors. High expression of ghrelin receptors reduces anxiety [3], while low levels have the opposite effect. Hence, it seems that long-term ibutamoren may exacerbate long-term stress, and brain ghrelin receptor down-regulation is the probable explanation. It seems likely, that transient or occasional increases in ghrelin receptor activation (such as after interval exercise [4]) may be more adaptive than chronic elevation regime.

[1] https://www.nature.com/articles/mp2013135

[2] https://www.ncbi.nlm.nih.gov/pubmed/22521145

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886665/

SARMs bans in China and USA

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In november 2019, USA started introducing SARMs control act that would make SARMs illegal to sell or possess but it has not become a law, yet (date: 02/14/2020) [1]. While China may have banned export of SARMs in the same time, several SARMs are bidded on alibaba.com [2]. In USA, the aim of SARMs ban is to protect the consumers from unscrupulous vendors that sell SARMs as food supplements as well as buyers that unknowingly buy food supplements unknowingly. On the other hand, it will also mean that selling and buying SARMs becomes criminal, even if these substances are considered as research chemicals by both parties.

The parties that support criminalization include entertainment sports industry, pharmaceutical industry and natural products industry: U.S. Anti-Doping Agency, the American Herbal Products Association, the Consumer Healthcare Products Association, the Council for Responsible Nutrition and the United Natural Products Alliance.

Enhancetech has most of the SARMs back in stock and there shouldn’t be any problem according to our manufacturer. We might not be able to ship to US, after SARMs control act would become a law. So we suggest all US customers to order SARMs as soon as possible.

[1] https://www.congress.gov/bill/116th-congress/senate-bill/2895
[2] www.alibaba.com
[3] https://www.grassley.senate.gov/news/news-releases/grassley-whitehouse-introduce-legislation-regulate-sarms

Summary of SARMs doses used in human studies

Nootropics, SARMs

Overview of SARMs dosages used in human studies.

Summary of SARMs doses used in human studies:

SARM/Nootropic and dosage used:
Ostarine 3 mg [1]
Ligandrol 1 mg [2]
YK-11 Unknown
RAD140 Unknown
Cardarine Unknown
SR9009 Unknown
SR9011 Unknown
Unifiram Unknown
PRL-5-83 5 mg [3]
Yohimbine Usually 5…30 mg [4],[5]
Hordenine Unknown but present in beer 1…6 mg [6]
PEA Unknown but see [6],[7]

[1] https://www.ncbi.nlm.nih.gov/pubmed/27138015
[2] https://www.ncbi.nlm.nih.gov/pubmed/27138015
[3] https://www.ncbi.nlm.nih.gov/pubmed/?term=PRL-8-
[5] https://www.ncbi.nlm.nih.gov/pubmed/9315493
[6] https://www.ncbi.nlm.nih.gov/pubmed/30409657
[7] https://www.ncbi.nlm.nih.gov/pubmed/26481102
[8] https://www.ncbi.nlm.nih.gov/pubmed/26481102

SR9009 (Stenabolic) now available

SARMs, SARMs online shop

We have added new SARM SR9009 to our provided products.

SR9009 also known as Stenabolic is an experimental circadian rhytm modulator (RevErb-alpha agonist). In one hand, SR9009 is said to be attractive as a performance-enhancing agent, yet. In the other hand, its use has been discouraged because it is potentially harmful. The desire to discourage its use has prompted development of its screening methods. So far, SR9009 has revealed anti-inflammatory properties (suppressing activation of several pro-inflammatory cytokines including tumor necrosis factor alfa, whose downstream effect was suppression of tumor necrosis factor alpha). The anti-inflammatory effects have been shown in animal models of endometriosis, heart attack, Alzheimer’s disease and some autoimmune diseases.

Read more about SR9009 or buy SR9009 in our store.