What kind of performance enhancers are PDE-5 inhibitors?

What kind of performance enhancers are PDE-5 inhibitors?

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Phosphodiesterase 5 (PDE-5) inhibitors were originally investigated for hypertension because of their ability to relax blood vessels. To researchers’ surprise, inhibiting PDE-5 was even better for improving male erection. That’s why PDE-5 inhibitors such as sildenafil or tadalafil are most commonly marketed for improving erectile function. Relaxing blood vessels may be beneficial for purposes of exercise. PDE-5 inhibitors have potential to increase endurance performance because it counteracts contraction of blood vessels in lungs [1].

Clinical studies have shown that sildenafil and tadalafil can improve exercise capacity in certain patient populations. A proof-of-concept study demonstrated somewhat increased aerobic exercise capacity in young adult patients with cystic fibrosis, a disease that reduces lung function [2]. 25 mg of sildenafil increased the VOmax approximately 5% after four weeks of use while a single 50 mg dose failed to increase VOmax significantly despite some tendency to do so. There is some data that tadalafil increases exercise capacity of patients with pulmonary hypertension . It must be noted that the study subjects were those who could not walk 4.5 km/h for 10 minutes [3] and about third of the patients suffered from headache as an side effect.

In diabetic but not in healthy women, tadalafil has been shown to increase glucose utilization in the muscle [5]. In cyclists, sildenafil did not improve the results in the context of 16.1 km exercise [1]. On the negatice side, tadalafil is associated with yet unexplained higher incidence of back pain in clinical studies. About 8.3% to 9.4% of men taking tadalafil suffered from back pain while only 3.4% of men in placebo group suffered from back pain — the risk is greater than two-fold [6]. There was no difference in blood parameters. Hence, the increased incidence of back pain lacks explanation. One might ask if the back pain is associated with increased strenuous sexual performance. Anabolic steroid users seem to use PDE-5 inhibitors mainly for sexual enhancement also [7]. In mice, PDE-5 inhibitors can increase the production of testosterone [8].

In men – possible but unlikely. The scientific consensus based on several human studies is that PDE-5 inhibitors do not increase testosterone production. PDE-5 inhibitors are beneficial for semen but, again, in infertile rather than healthy men [9]. It seems unlikely that PDE-5 inhibitors augment testosterone. It is the other way around, instead [10]. PDE-5 inhibitors are sexual performance enhancers that just happen to be performance enhancers in serious lung disease patients.

Don´t hesitate to ask it.

[1] https://pubmed.ncbi.nlm.nih.gov/30653578/
[2] https://pubmed.ncbi.nlm.nih.gov/31803404/
[3] https://pubmed.ncbi.nlm.nih.gov/19470885/
[4] https://pubmed.ncbi.nlm.nih.gov/4377045/
[5] https://pubmed.ncbi.nlm.nih.gov/20535445/
[6] https://pubmed.ncbi.nlm.nih.gov/16034469/
[7] https://pubmed.ncbi.nlm.nih.gov/31303195/
[8] https://pubmed.ncbi.nlm.nih.gov/19659904/
[9] https://pubmed.ncbi.nlm.nih.gov/28259808/
[10] https://pubmed.ncbi.nlm.nih.gov/24251448/

 

Michael’s feedback

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Hi Enhancetech

Here’s a picture of me taken 2 months between this summer. In this period I used cardarine and ostarine. I combination with 2/4 protein, 1/4 carbs and 1/4 fats I felt the shredding process even after a few days. Luckily, as you can see, I had noticable gains in muscle size too.

Great products which I will use over and over again! Very pleased.

Kind regards,
Michael

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Igor Buracof feedback

Igor Buracof feedback

Customers Feedback, SARMs, SARMs online shop

Hello everyone

I would like to share my personal experience with SARMS to be more precisely the experience was only with SARMS made from enhancetech.
I started to take SARMS around 20/nov/2020. In the beginning I was bulking and it gave me a lot of strength, stamina and power during the workout session, I was into and RAD140, LGD-4033 and YK11 .
Then I moved to cut using MK-677 and RAD140. Was around 80 days with this cycle and it worked greatly. I would like to share bellow my before and after picture.

Igor Buracof

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Igor on the beach today

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BEFORE

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AFTER

Get 10% off with cryptocurrency payout option

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We are offering extra 10% discount when paying for SARMs and Nootropics by cryptocurrency.

Discount appears in checkout, when choosing “Bitcoin or other cryptocurrency” payment method. We are providing this as as we don’t have to pay credit card charging fees or other type of fees. At the same time we are supporting philosophy behind the cryptocurrency.

We accept Bitcoin, Ethereum, Bitcoin cash. For other cryptocurrency, please contact us.

Please see our shop for all our provided products.

SARMs bans in China and USA

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In november 2019, USA started introducing SARMs control act that would make SARMs illegal to sell or possess but it has not become a law, yet (date: 02/14/2020) [1]. While China may have banned export of SARMs in the same time, several SARMs are bidded on alibaba.com [2]. In USA, the aim of SARMs ban is to protect the consumers from unscrupulous vendors that sell SARMs as food supplements as well as buyers that unknowingly buy food supplements unknowingly. On the other hand, it will also mean that selling and buying SARMs becomes criminal, even if these substances are considered as research chemicals by both parties.

The parties that support criminalization include entertainment sports industry, pharmaceutical industry and natural products industry: U.S. Anti-Doping Agency, the American Herbal Products Association, the Consumer Healthcare Products Association, the Council for Responsible Nutrition and the United Natural Products Alliance.

Enhancetech has most of the SARMs back in stock and there shouldn’t be any problem according to our manufacturer. We might not be able to ship to US, after SARMs control act would become a law. So we suggest all US customers to order SARMs as soon as possible.

[1] https://www.congress.gov/bill/116th-congress/senate-bill/2895
[2] www.alibaba.com
[3] https://www.grassley.senate.gov/news/news-releases/grassley-whitehouse-introduce-legislation-regulate-sarms

SR9009 (Stenabolic) now available

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We have added new SARM SR9009 to our provided products.

SR9009 also known as Stenabolic is an experimental circadian rhytm modulator (RevErb-alpha agonist). In one hand, SR9009 is said to be attractive as a performance-enhancing agent, yet, in the other hand, its use has been discouraged because it is potentially harmful. The desire to discourage its use has prompted development of its screening methods. So far, SR9009 has revealed anti-inflammatory properties (suppressing activation of several pro-inflammatory cytokines including tumor necrosis factor alfa, whose downstream effect was suppression of tumor necrosis factor alpha). The anti-inflammatory effects have been shown in animal models of endometriosis, heart attack, Alzheimer’s disease and some autoimmune diseases.

Read more about SR9009 or buy SR9009 in our store.

New SARM SR9011 available

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We have added new SARM SR9011 to our product list.

SR9011 is a novel circadian clock amplifier not yet tested in humans but is already a suspected performance enhancing agent. In mice, it has reduced blood fat and sugar levels while it increased energy expenditure and appetite. SR9011 had mild or nightlong interaction with wakefulness depending on light conditions, has anti-inflammatory properties and does not have overt toxicity. In a few cell lines it did not interfere with proliferation of normal cell lines specifically. Hence, Rev-ErbA? agonists, as shown by at least four lines of evidence, seem to have a broad spectrum of effects.

Read more about SR9011 or buy SR9011 in our store.

Using cryptocurrency to buy SARMs

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Enhancetech accepts cryptocurrency payments. We support Bitcoin (BTC), Ethereum (ETH) and Bitcoin Cash (BCH).

Cryptocurrencies are getting more popular and many of our customers would like to use cryptocurrencies to pay for their orders. We are accepting main cryptocurrencies like Bitcoin, Ethereum and Bitcoin Cash. If needed we can accept also other common currencies like Litecoin, just let us know.

By using cryptocurrency to pay, we still need you to accept our sale terms. Please remember all our products, including SARMs, are for research use only.

 

 

Credit card payments and new batch of products

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We have added credit card payments to Enhancetech web shop. Also there are new batch of products available.

Credit Card payments doesn’t include direct payments, but after checkout specific instructions will be sent. There is still option for SEPA payments, which means easy and quite fast bank transfers in EU countries.

There is also updates in our stock. Currently we are out of YK11, Ibutamoren and NSI-189, rest of the products are available for ordering.