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What is ibutamoren, MK-677?
Ibutamoren is an analogue of the hunger hormone (ghrelin) that has been researched for use in growth hormone deficit in children, elderly trauma recovery and sports.
Ibutamoren, body weight and body composition
In a study of overweight men, MK-677 did not help to decrease weight. However, ibutamoren increased muscle mass but left the fat mass unchanged. The side effect profile was favorable in that study. Ibutamoren is of no interest for weight loss research. Exactly opposite is true. In a young men’s study, ibutamoren prevented body mass loss. Ibutamoren has improved body composition (increased muscle %, decreased fat %), with good tolerability and no apparent side effects. Relatively minor side effects of ibutamoren are increasing cortisol levels and reducing insulin sensitivity. Excessive cortisol reduces bone density, reduced insulin sensitivity reduces gaining muscle mass. However, the main effect of ibutamoren overshadow these side effects because it both improves bone density and muscle mass.
In a study of elderly with a hip fracture, the researchers observed practical adverse effects. While ibutamoren helped the elderly subjects to climb the stairs more effectively, ibutamoren was not recommended because of too frequent cardiovascular adverse effects that were fairly serious. Moreover, mk-677 is a mixed bag in relation to cancer: in one study it inhibited cancer cells, in the second study it did nothing and in the third study it stimulated hormone-producing cancer cells. Therefore it seems that ibutamoren is a fairly dangerous research chemical for the elderly.
Ibutamoren, sleep, and anxiety
The connection between mk-677 and sleep has been studied in a small study. Above all, the effects of the preliminary study suggested increased sleep quality. This is quite unusual because sleep quality is difficult to improve. Most common pharmaceutical sleeping pills, alcohol, nicotine and caffeine decrease sleep quality. Ibutamoren may interact with anxiety but the interaction is complex and the research in early stage. It seemed to reduce anxiety in the short and to increase it in the long term. My subjective experience with mk-677 definitely agrees with improved sleep. A decrease in anxiety in short-term and increase in long term was not experienced first hand because ibutamoren is not psychoactive. An episode of insomnia and moderate anxiety was experienced after a few weeks after stopping ibutamoren. However, I did not experience acute withdrawal-like reaction.
RAD140 is a novel (selective androgen receptor modulator – SARM). In other words selectively supports muscle growth over prostate growth. To clarify, in lower doses, it does not stimulate prostate growth. At the same time, it is reasonable, to speculate that the side-effects (prostate growth) could increase. As a result expected, it lowered the “good” and “bad” cholesterol. In conclusion, it does not cause liver damage. Read more about RAD140.
Cardarine is agonist of PPAR? In other words, receptor that intensifies lipid metabolism. In other words, it makes the body to use lipids more effectively. Therefore, it have an attractive effect. Certainly cardarin alone is not enough to cause weight loss. Therefore, you need to altering the energy intake balance. However, the effects of cardarine, appear as quite exact opposite to the stereotypical “bad western diet”. Likewise alteration of “bad” LDL and “good” HDL cholesterol levels. To clarify, it has different effects in different doses according to clinical studies:
Table – Dose-dependent effects of cardarine at six weeks:
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GW501516 is under scrutiny. In other words, it can support or suppress tumor cell activity. In conclusion, it is considered as a doping substance.
- Firstly, it increases endurance
- It also improves the blood profile associated with a high carbohydrate and high fat diet
- Immunomodulation (reduction of IL-6)
- In conclusion, it helps to gain weight at higher doses
Read more about Cardarine.