While the results regarding the effects of PRL-8-53 was published in 1978, and is considered perhaps the best verbal memory improving agent by nootropic community. However it has remained relatively obscure. In spite of the increased proportion of aging population with memory impairment in one hand and, possibly, increased need to study in advanced age in developed countries. PRL-8-53 is the best verbal memory improving agent. Increases verbal reminding in the elderly.
Truthfully, there is not much research information about PRL-8-53 other than the original study. It remarkably increased verbal recall, especially in the subjects with initially poorer memory without acute side effects. Higher doses motor function and have spasmolytic properties. The mechanism of action is unknown. But PRL-8-53 seems to counteract monoamine depleting drug reserpine. However yet without possessing stimulant properties. The mechanisms may be associated with potentiating effects of acetylcholine and dopamine. however counteracting serotonin. Considering rather promising results of the preliminary study, the paucity of further research seems outright disturbing in the light of the current challenges that present themselves to the population of today.
- Firstly, verbal memory improving
- Secondly, increases verbal reminding in the elderly.
- In conclusion, increased need to study in advanced age.
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