What’s the Positive Interaction Between Ligandrol, RAD140 and Ibutamoren?

What’s the Positive Interaction Between Ligandrol, RAD140 and Ibutamoren?

SARMs, SARMs online shop, Uncategorized

Ligandrol (LGD-4033) is a selective androgen receptor modulator (SARM). In a short (21-day) placebo-controlled human study, participants gained lean body mass, alongside expected hormonal suppression.

RAD140 (Testolone) is another SARM. Most of what we know comes from preclinical work describing potent, tissue-selective androgen-receptor activity.

Ibutamoren (MK-677) isn’t a SARM. It’s an oral growth-hormone secretagogue (a ghrelin-receptor agonist) that raises GH and IGF-1. Human trials show increases in IGF-1 and, in select groups, fat-free mass during treatment.

Where a “stack” might seem complementary

Think of two anabolic highways working in parallel:

  1. Androgen-receptor signaling (LGD-4033, RAD140) is tied to muscle protein synthesis and strength adaptations.
  2. GH/IGF-1 signaling (MK-677) can influence recovery, sleep quality for some users, and nitrogen retention.

In theory, combining them could target distinct pathways that together support hypertrophy and training tolerance. In practice, controlled human data on the combination are lacking, so “synergy” is a mechanistic hypothesis, not a clinical fact.

How long until you might see anything?

Meaningful body-composition changes rarely appear overnight. Trials with MK-677 and LGD-4033 measured hormonal and lean-mass shifts over weeks to months, and effects typically persisted only while on treatment. If you’re going to evaluate a program built around these compounds, a minimum of ~3 months is a realistic appraisal window. Conveniently, Enhancetech’s “Gain Force” kit is packaged as a three-month supply of Ligandrol, RAD140 and Ibutamoren.
Expect to assess results no sooner than ~12 weeks of consistent training, nutrition and sleep. Anything shorter is hard to judge.

Important caveats & compliance

The FDA has cautioned consumers about SARMs due to potential risks (including liver injury and cardiovascular events) and the fact that these are unapproved for human use.


LGD-4033 and RAD140 are prohibited at all times by WADA. Athletes subject to anti-doping rules should avoid them altogether.

MK-677 can impair glucose tolerance in some settings, and SARMs have been linked (in case reports/series) with liver injury. Medical supervision is prudent.

Where to find the SARMS stack

Our e-shop offers the “Gain Force” kit (LGD-4033 + RAD140 + MK-677) specifically as a 3-month bundle aimed at strength, mass and recovery support per vendor description. 

References

Basaria S, et al. The Safety, Pharmacokinetics, and Effects of LGD-4033… (21-day human trial).
Miller CP, et al.; ACS Med Chem/PMC: discovery & characterization of RAD140 (preclinical). American Chemical Society Publications.
Nass R, et al. Effects of an Oral Ghrelin Mimetic (MK-677) on Body Composition and Clinical Outcomes in Older Adults.
Svensson J, et al. Two-month MK-677 in healthy obese men: sustained GH/IGF-1 rise; OGTT impairment. PubMedSmith RG, 2023 review of growth-hormone secretagogues (duration-dependent effects). Oxford Academic.

Gain_force_three_months_kit_ligandrol_10mg_rad140_10mg_ibutamoren_25mg_sarms
Unveiling the Potential: How SARMS Help Control Bad Cholesterol

Unveiling the Potential: How SARMS Help Control Bad Cholesterol

SARMs, SARMs online shop

In the quest for physical fitness and wellness, the landscape of supplements and performance enhancers is ever-evolving. One category that has garnered attention in recent years is Selective Androgen Receptor Modulators, or SARMS. While primarily known for their muscle-building properties. SARMS also hold promise in managing cholesterol levels, specifically control bad cholesterol, or LDL (Low-Density Lipoprotein). Let’s delve into how SARMS might be a potential ally in the battle against high LDL cholesterol.

Understanding Cholesterol

Before we explore the relationship between SARMS and cholesterol, it’s crucial to grasp the role of cholesterol in the body. Cholesterol is a waxy, fat-like substance found in every cell of the body and is essential for building cell membranes, producing hormones, and aiding in the digestion of fat. However, when cholesterol levels become imbalanced. It can lead to atherosclerosis, a condition characterized by the accumulation of plaque in the arteries. Increasing the risk of heart disease and stroke.

Cholesterol exists in different forms within the body. High-Density Lipoprotein (HDL) is often referred to as “good” cholesterol as it helps remove LDL from the arteries, transporting it to the liver for excretion. On the other hand, LDL, or “bad” cholesterol. It can build up in the arteries, leading to blockages and potentially dangerous health conditions.

SARMS: More Than Muscle Builders?

Selective Androgen Receptor Modulators were initially developed to treat conditions like muscle wasting and osteoporosis. They work by selectively binding to androgen receptors in the body, influencing gene expression that leads to muscle growth and bone density improvement. However, recent research suggests that SARMS might have additional benefits beyond their primary muscle-building function.

The Link Between SARMS and Cholesterol

While studies on SARMS are still in their infancy compared to other pharmaceuticals, there is emerging evidence to suggest that SARMS could impact cholesterol levels. One study published in the Journal of Pharmacology and Experimental Therapeutics found that a specific SARM known as S-23 and RAD-140 demonstrated a significant reduction in LDL cholesterol levels in rats. Similarly, another study published in the Journal of Steroid Biochemistry and Molecular Biology reported that another SARM, GTx-024 (also known as enobosarm or ostarine), decreased LDL cholesterol levels in monkeys.

These findings are promising, indicating that SARMS might not only enhance physical performance but also contribute to cardiovascular health by lowering LDL cholesterol levels. However, it’s essential to note that research on SARMS and cholesterol in humans is limited. And more comprehensive studies are needed to fully understand their effects and potential benefits.

In Conclusion

While SARMS hold promise as a potential tool in managing cholesterol levels. Particularly LDL cholesterol, more research is needed to validate their efficacy and safety in humans. As of now, lifestyle modifications such as regular exercise, a balanced diet, and medication prescribed by healthcare professionals remain the cornerstone of cholesterol management.

As the scientific community continues to explore the multifaceted effects of SARMS. It’s essential to approach their use with caution and prioritize evidence-based practices in pursuit of optimal health and wellness.

blocked-vessel-in-high-level-of-LDL-bad-cholesterol-lipoprotein

SARMs Comparison table

SARMs Comparison table

SARMs, SARMs online shop

Cardarine, Ostarine and Ibutamoren are very different performance-enhancing research chemicals SARMs. All three have been moderately well researched.

Cardarine increases endurance and lipid metabolism. I´ts microdose elevates good cholesterol.

Ostarine mimics the anabolic effects of testosterone more selectively than anabolic steroids. It´s relatively non-toxic; alas, users of high doses have been hospitalized due to adverse effects similar to anabolic steroids (liver toxicity).

Ibutamoren is a synthetic analogue of hunger hormone. That alters the intensity rather than pattern of growth hormone secretion.

Larger doses have probably higher risk of adverse effects. Recently, it was even suggested that cardarine is dangerous when combined with a SARM (ostarine). While it may tempting to think that cardarine would be a good means to reduce the side effects of SARMs or ibutamoren, it may be a bad idea. Recently, it was suggested that combination of cardarine and ostarine is toxic. At least after prolonged use of the combination. The following table shows both desirable and undesirable effects of these three major performance-enhancing chemicals.

Comparison_table_of_cardarine_orstarine_and_ibutamoren_effects
Comparison_table_of_cardarine_orstarine_and_ibutamoren_effects

https://pubmed.ncbi.nlm.nih.gov/19852734/

https://pubmed.ncbi.nlm.nih.gov/31642815/

https://pubmed.ncbi.nlm.nih.gov/9467542/

https://pubmed.ncbi.nlm.nih.gov/18981485/

https://pubmed.ncbi.nlm.nih.gov/10372705/

https://pubmed.ncbi.nlm.nih.gov/9329386/

https://pubmed.ncbi.nlm.nih.gov/22814748/

https://pubmed.ncbi.nlm.nih.gov/14525954/

https://pubmed.ncbi.nlm.nih.gov/25854303/

https://pubmed.ncbi.nlm.nih.gov/17110604/

https://pubmed.ncbi.nlm.nih.gov/34678947/

https://pubmed.ncbi.nlm.nih.gov/20602678/

https://pubmed.ncbi.nlm.nih.gov/32876707/

https://pubmed.ncbi.nlm.nih.gov/29785666/

https://pubmed.ncbi.nlm.nih.gov/22031847/

https://pubmed.ncbi.nlm.nih.gov/24708238/

What kind of performance enhancers are PDE-5 inhibitors?

What kind of performance enhancers are PDE-5 inhibitors?

SARMs online shop, Uncategorized

Phosphodiesterase 5 (PDE-5) inhibitors were originally investigated for hypertension because of their ability to relax blood vessels. To researchers’ surprise, inhibiting PDE-5 was even better for improving male erection. That’s why PDE-5 inhibitors such as sildenafil or tadalafil are most commonly marketed for improving erectile function. Relaxing blood vessels may be beneficial for purposes of exercise. PDE-5 inhibitors have potential to increase endurance performance because it counteracts contraction of blood vessels in lungs [1].

Clinical studies have shown that sildenafil and tadalafil can improve exercise capacity in certain patient populations. A proof-of-concept study demonstrated somewhat increased aerobic exercise capacity in young adult patients with cystic fibrosis, a disease that reduces lung function [2]. 25 mg of sildenafil increased the VOmax approximately 5% after four weeks of use while a single 50 mg dose failed to increase VOmax significantly despite some tendency to do so. There is some data that tadalafil increases exercise capacity of patients with pulmonary hypertension . It must be noted that the study subjects were those who could not walk 4.5 km/h for 10 minutes [3] and about third of the patients suffered from headache as an side effect.

In diabetic but not in healthy women, tadalafil has been shown to increase glucose utilization in the muscle [5]. In cyclists, sildenafil did not improve the results in the context of 16.1 km exercise [1]. On the negatice side, tadalafil is associated with yet unexplained higher incidence of back pain in clinical studies. About 8.3% to 9.4% of men taking tadalafil suffered from back pain while only 3.4% of men in placebo group suffered from back pain — the risk is greater than two-fold [6]. There was no difference in blood parameters. Hence, the increased incidence of back pain lacks explanation. One might ask if the back pain is associated with increased strenuous sexual performance. Anabolic steroid users seem to use PDE-5 inhibitors mainly for sexual enhancement also [7]. In mice, PDE-5 inhibitors can increase the production of testosterone [8].

In men – possible but unlikely. The scientific consensus based on several human studies is that PDE-5 inhibitors do not increase testosterone production. PDE-5 inhibitors are beneficial for semen but, again, in infertile rather than healthy men [9]. It seems unlikely that PDE-5 inhibitors augment testosterone. It is the other way around, instead [10]. PDE-5 inhibitors are sexual performance enhancers that just happen to be performance enhancers in serious lung disease patients.

Don´t hesitate to ask it.

[1] https://pubmed.ncbi.nlm.nih.gov/30653578/
[2] https://pubmed.ncbi.nlm.nih.gov/31803404/
[3] https://pubmed.ncbi.nlm.nih.gov/19470885/
[4] https://pubmed.ncbi.nlm.nih.gov/4377045/
[5] https://pubmed.ncbi.nlm.nih.gov/20535445/
[6] https://pubmed.ncbi.nlm.nih.gov/16034469/
[7] https://pubmed.ncbi.nlm.nih.gov/31303195/
[8] https://pubmed.ncbi.nlm.nih.gov/19659904/
[9] https://pubmed.ncbi.nlm.nih.gov/28259808/
[10] https://pubmed.ncbi.nlm.nih.gov/24251448/

Michael’s feedback

Customers Feedback, SARMs, SARMs online shop

Hi Enhancetech

Here’s a picture of me taken 2 months between this summer. In this period I used cardarine and ostarine. I combination with 2/4 protein, 1/4 carbs and 1/4 fats I felt the shredding process even after a few days. Luckily, as you can see, I had noticable gains in muscle size too.

Great products which I will use over and over again! Very pleased.

Kind regards,
Michael

Michael_heimlund_customer_feedback

Igor Buracof feedback

Igor Buracof feedback

Customers Feedback, SARMs, SARMs online shop

Hello everyone

I would like to share my personal experience with SARMS to be more precisely the experience was only with SARMS made from enhancetech.
I started to take SARMS around 20/nov/2020. In the beginning I was bulking and it gave me a lot of strength, stamina and power during the workout session, I was into and RAD140, LGD-4033 and YK11 .
Then I moved to cut using MK-677 and RAD140. Was around 80 days with this cycle and it worked greatly. I would like to share bellow my before and after picture.

Igor Buracof

enhancetech client feedback

Igor on the beach today

enhancetech client feecbackenhancetech client feedback

BEFORE

enhancetech client feedbackenhancetech client feedback

AFTER

Get 10% off with cryptocurrency payout option

SARMs online shop

We are offering extra 10% discount when paying for SARMs and Nootropics by cryptocurrency.

Discount appears in checkout, when choosing “Bitcoin or other cryptocurrency” payment method. We are providing this as as we don’t have to pay credit card charging fees or other type of fees. At the same time we are supporting philosophy behind the cryptocurrency.

We accept Bitcoin, Ethereum, Bitcoin cash. For other cryptocurrency, please contact us.

Please see our shop for all our provided products.

SARMs bans in China and USA

SARMs, SARMs online shop

In november 2019, USA started introducing SARMs control act that would make SARMs illegal to sell or possess but it has not become a law, yet (date: 02/14/2020) [1]. While China may have banned export of SARMs in the same time, several SARMs are bidded on alibaba.com [2]. In USA, the aim of SARMs ban is to protect the consumers from unscrupulous vendors that sell SARMs as food supplements as well as buyers that unknowingly buy food supplements unknowingly. On the other hand, it will also mean that selling and buying SARMs becomes criminal, even if these substances are considered as research chemicals by both parties.

The parties that support criminalization include entertainment sports industry, pharmaceutical industry and natural products industry: U.S. Anti-Doping Agency, the American Herbal Products Association, the Consumer Healthcare Products Association, the Council for Responsible Nutrition and the United Natural Products Alliance.

Enhancetech has most of the SARMs back in stock and there shouldn’t be any problem according to our manufacturer. We might not be able to ship to US, after SARMs control act would become a law. So we suggest all US customers to order SARMs as soon as possible.

[1] https://www.congress.gov/bill/116th-congress/senate-bill/2895
[2] www.alibaba.com
[3] https://www.grassley.senate.gov/news/news-releases/grassley-whitehouse-introduce-legislation-regulate-sarms

SR9009 (Stenabolic) now available

SARMs, SARMs online shop

We have added new SARM SR9009 to our provided products.

SR9009 also known as Stenabolic is an experimental circadian rhytm modulator (RevErb-alpha agonist). In one hand, SR9009 is said to be attractive as a performance-enhancing agent, yet. In the other hand, its use has been discouraged because it is potentially harmful. The desire to discourage its use has prompted development of its screening methods. So far, SR9009 has revealed anti-inflammatory properties (suppressing activation of several pro-inflammatory cytokines including tumor necrosis factor alfa, whose downstream effect was suppression of tumor necrosis factor alpha). The anti-inflammatory effects have been shown in animal models of endometriosis, heart attack, Alzheimer’s disease and some autoimmune diseases.

Read more about SR9009 or buy SR9009 in our store.

New SARM SR9011 available

SARMs, SARMs online shop

We have added new SARM SR9011 to our product list.

SR9011 is a novel circadian clock amplifier not yet tested in humans but is already a suspected performance enhancing agent. In mice, it has reduced blood fat and sugar levels while it increased energy expenditure and appetite. Agent had mild or nightlong interaction with wakefulness depending on light conditions, has anti-inflammatory properties and does not have overt toxicity. In a few cell lines it did not interfere with proliferation of normal cell lines specifically. Hence, Rev-ErbA? agonists, as shown by at least four lines of evidence, seem to have a broad spectrum of effects.

Read more about SR9011 or buy SR9011 in our store.